HEST

A vision for the future, grounded in reality.

Founded in 2023, HEST Ventures backs founders applying visionary science to pressing unmet needs. We seek technical solutions with development strategies that clearly demonstrate value to markets.

We have written the first outside check into many of the companies we’ve backed, and we have the patience to see a project through to the end.

• Life sciences
• Quantum
• Info Tech
• Deep Tech

Disciplined investors with an operator mindset.

HEST is principal-led and personally engaged with every company it backs — decisions are made by the people whose capital is at work, not by committee.

• Dallas, TexasLife sciencesDetails

  Life sciencesClinical-stage cell therapy from neonatal cardiac progenitor cells and their secretome. STM-01 holds FDA Fast Track for heart failure (HFpEF).secretometherapeutics.comClose
• Seattle, WashingtonLife sciencesDetails

  Life sciencesTargeted oncology led by Seagen co-founder Clay Siegall (Nasdaq: IMNM). NDA submitted for varegacestat in desmoid tumors.immunome.comClose
• Starbase, TexasDeep techDetails

  Deep techFalcon, Starship, and Starlink — the reusable-launch company that reset the economics of space.spacex.comClose
• Ann Arbor, MichiganDeep techDetails

  Deep techIntelligent battery components built from aramid nanofibers, spun out of University of Michigan materials research.valerion.energyClose
• Princeton, New JerseyLife sciencesDetails

  Life sciencesUniversal platform for CAR T-cell therapy in solid tumors.monarchtherapeutics.comClose
• Bay Area, CaliforniaLife sciencesDetails

  Life sciencesPreclinical melanocortin medicines for obesity and wasting — MC4R and MC3R programs.couragetx.comClose
• Seattle, WashingtonQuantumDetails

  QuantumPost-quantum cryptography for enterprise data in transit — the Ambit Client VPN runs CNSA 2.0-compliant algorithms across every cryptographic component, built for the harvest-now, decrypt-later era.ambit.incClose
• Dallas, TexasLife sciencesDetails

  Life sciencesEarly-stage company redefining non-invasive skincare.infiniteyouth.ioClose
• Houston, TexasDeep techDetails

  Deep techKinetic energy storage on high-temperature superconducting bearings: 2 MW flywheel modules delivering grid inertia, AI data-center ride-through, and fast EV charging.revterra.ioClose
• Bay Area, CaliforniaLife sciencesDetails

  Life sciencesStealth-stage biopharmaceutical company advancing differentiated medicines for CNS patient populations with high unmet need.arctherapeutics.bioClose
• Austin, TexasLife sciencesDetails

  Life sciencesTargeted delivery via the body's cholesterol transport system, aimed at tumor metabolism. NIH/NCI Innovative Concept Award.qanatx.comClose
• RTP, North CarolinaLife sciencesDetails

  Life sciencesVenture studio transforming breakthrough academic science into companies, with ventures spanning RNA therapeutics, exosome immunotherapy, antivirals, cell therapy, and hemostatics.persephonibio.comClose
• San Diego, CaliforniaLife sciencesDetails

  Life sciencesSynthetic, human-identical GM1 ganglioside as the first disease-modifying therapeutic for Parkinson's — built on Phase 2 evidence that GM1 slows progression.renascentneuroscience.comClose
• Dallas, TexasInfo techDetails

  Info techAI-driven payment integrity for healthcare — pre-pay review to post-pay recovery in one loop. Founded 2012.claimreturn.comClose
• Los Angeles, CaliforniaInfo techDetails

  Info techAgentic AI platform orchestrating thousands of models and tools into a 24/7 enterprise workforce — automating workflows privately and securely, in minutes rather than weeks. An NVIDIA Inception company.magieva.comClose